At least seven submarines, and likely more, are part of the effort.
The USS Delaware, a fast attack submarine, was commissioned administratively and transitioned to normal operations Saturday.
Of a world in coronavirus turmoil, they may know little or nothing.
The "excessive speed" of the sub as it approached the pilot pick-up made it more difficult for the crew to control the ship.
It was the country's worst nuclear submarine disaster when Thresher did not surface while conducting deep dive exercises.
U.S. ships leaving the East Coast must now consider the Atlantic Ocean a contested battlespace, a Navy three-star said.
The debut deployment aboard long-range submarines, known as boomers, is a landmark in U.S. nuclear weapons policy.
The move brings back into service the hallowed ship names 78 years after both were badly damaged on Dec. 7, 1941.
Viktor Leonov also has been spotted sailing off the coast of South Carolina in recent days.
Lauren Bruner, mong the last sailors rescued from the Arizona, died in September at age 98.